胡艳平1, 2,张 颖1, 2,马中良2*,李 谦1*
(1 中国药科大学生命科学与技术学院,南京 210009 ;2 上海大学生命科学学院非编码RNA与癌症实验室,上海 200444)

摘 要:摘 要:MicroRNA-183 基因簇是包括miR-183、miR-96 和miR-182 在内的一类非编码RNA 中的microRNA基因簇。近年来,研究发现它们在一些癌症、神经紊乱和自身免疫失调等疾病中异常表达,尤其在一些肿瘤中高表达而促进癌症的发生发展。因此,microRNA-183 基因簇能为癌症的治疗和诊断提供强有力的靶点和研究方向。现综述近年来microRNA-183 基因簇在常见恶性肿瘤中作为肿瘤生物标志物,及其在癌症中调控机理的研究进展,为microRNA-183 基因簇在癌症的临床应用提供方向。

Research progress on diagnosis and regulatory mechanisms of microRNA-183 cluster in cancers
HU Yan-Ping1, 2, ZHANG Ying1, 2, MA Zhong-Liang2*, LI Qian1*
(1 School of Life Sciences and Technology, China Pharmaceutical University, Nanjing 210009, China; 2 Lab for Non-coding RNA and Cancer, School of Life Sciences, Shanghai University, Shanghai 200444, China)

Abstract: Abstract: MicroRNA-183 cluster is a microRNA cluster composed of miR-183, miR-96 and miR-182. In recent years, they are found to be dysregulated in cancers, neuronal disorders and auto-immune disorders, especially upregulated in some tumors. It indicates that microRNA-183 cluster could be a tumor-driver gene. This article summarizes the progress of microRNA-183 cluster as diagnostic biomarkers in common malignancies and the roles in tumorgenesis. It may provide a novel strategy for clinical application.

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