《生命科学》 2018, 30(5): 551-558

Wnt信号通路对细胞增殖的调控

张宁芳，高鹏飞，成志敏，乐宝玉，郭晓红，李步高，曹果清*

(山西农业大学动物科技学院，太谷 030801)

摘　要：摘　要：Wnt 信号通路是一种在进化上高度保守的信号通路，在机体细胞的生长、发育以及代谢平衡等过程中发挥重要作用。细胞增殖是生物体生长、发育和遗传的基础。许多研究发现，Wnt 信号通路中关键分子的变化会促进或抑制细胞增殖。现综述Wnt 信号通路的组成、调控机理以及Wnt 信号通路对细胞增殖的调控，并讨论基于Wnt 信号通路影响细胞增殖的理论开发治疗癌症药物的可能性。

Regulation of the Wnt signaling pathway on cell proliferation

ZHANG Ning-Fang， GAO Peng-Fei， CHENG Zhi-Min， LE Bao-Yu， GUO Xiao-Hong， LI Bu-Gao， CAO Guo-Qing*

(College of Animal Science and Veterinary Medicine， Shanxi Agricultural University， Taigu 030801， China)

Abstract: Abstract: Wnt signaling pathway is evolutionarily conserved， and has multiple biological functions during animal growth and development， and metabolic balance regulation. Cell proliferation is the base of genetics， growth and development. Previous studies demonstrate that alteration of Wnt signaling component either enhance or inhibit cell proliferation. In this review， the composition and regulation mechanisms of Wnt signaling pathway were summarized， and its effect on cell proliferation was reviewed. Additionally， possibility for developing new drugs targeted Wnt signaling pathway for cancer treatment was discussed.