《生命科学》 2018, 30(5): 526-532
摘 要：摘 要：白细胞介素(interleukin， IL)-26 最初被认为由T 细胞特别是辅助性T 细胞17 产生。最近的研究发现，自然杀伤细胞、巨噬细胞、成纤维细胞和血管平滑肌细胞也产生IL-26。研究显示，IL-26 能够特异性地结合到靶细胞的 IL-10R2/IL-20R1 受体复合物上，产生特定的胞内信号。除此以外，IL-26 还可直接杀灭胞外细菌，并能与死亡细菌DNA 或死亡细胞DNA 片段结合形成IL-26-DNA 复合物，激活浆细胞样树突状细胞Toll 样受体9，分泌Ⅰ型干扰素IFN-α，在宿主防御和慢性炎性疾病中发挥重要作用。现对IL-26 的结构、来源、受体和功能等进行综述。
Abstract: Abstract: Interleukin (IL)-26 was originally thought to be produced by T cells， especially the helper T cells 17. Recent studies have proved that natural killer cells， macrophages， fibroblasts and vascular smooth muscle cells can also produce IL-26. IL-26 has been proved to produce specific intracellular signatures， according to the IL-10R2/IL-20R1 receptor complexes. In addition， IL-26 can kill extracellular bacteria and form complexes with bacterial DNA and self-DNA released by dying bacteria and host cells. The IL-26-DNA complexes stimulate the secretion of type I interferon α by plasmacytoid dendritic cells via activation of Toll-like receptor 9. These findings provide insights into an important role of IL-26 in host defense and chronic inflammatory diseases. In the review， we summarized the structure， source， receptor and functions of IL-26.
