《生命科学》 2018, 30(5): 510-516

胆固醇前体分子链甾醇的生理病理研究进展

高天琦，杨宝瑜，芦秀丽*

(辽宁大学生命科学院，沈阳 110036)

摘　要：摘　要：高胆固醇血症是动脉粥样硬化症等心脑血管疾病发病和进展的重要发病因素，因而降低胆固醇成为防治心脑血管疾病的重要治疗策略，但降低胆固醇并不是越低越好。链甾醇(24- 脱氢胆固醇) 是胆固醇合成的主要前体分子，在分子结构方面与胆固醇仅仅在支链上有一个C=C 双键的差别，因此在某些方面可以替代胆固醇，但在某些方面有其独特的功能，且不能替代胆固醇。现综述胆固醇与链甾醇的结构特点及生理功能，以期为降血脂的新药研发和临床治疗提供更多参考。

Research and development on the physiological functions of cellular desmosterol， a cholesterol precursor molecule

GAO Tian-Qi， YANG Bao-Yu， LU Xiu-Li*

(School of Life Science， Liaoning University， Shenyang 110036， China)

Abstract: Abstract: Hypercholesterolemia is an important risk factor in the pathogenesis and progression for cardiovascular disease such as atherosclerosis. Lowering cholesterol therefore has become an important therapeutic strategy for prevention and treatment of cardiovascular and cerebral vascular diseases. However， lowering cholesterol is not the lower the better. Desmosterol (24-dehydrocholesterol)， a major precursor molecule for cholesterol synthesis， which can be reduced to cholesterol as a substrate catalyzed by 24-dehydrocholesterol reductase (DHCR24). Desmosterol has a C and C double bond difference in molecular structure with cholesterol only in the branch chain. Desmosterol can replace cholesterol in some physiological functions while can not do it in some other aspects. This review summarizes the structural features and physiological functions of cholesterol and desmosterol， aiming to provide more references for the development of new drugs and clinical treatment for lowering blood fat.