《生命科学》 2018, 30(4): 473-479

蛋白质SUMO化修饰与疾病

郑　铨，程金科*

(上海交通大学医学院生物化学与分子细胞生物学系，上海 200025)

摘　要：摘　要：SUMO (small ubiquitin-related modifier) 化修饰作为一种可逆的蛋白质翻译后修饰，从发现至今已有20 余年。细胞内被确认能发生SUMO 化修饰的蛋白质已超过3 000 种。SUMO 化修饰能够调控蛋白质的活性，从而影响细胞内诸多生命活动过程，参与了对细胞生理与病理过程的调控。该综述在简要介绍蛋白质SUMO 化修饰的基础上，将重点介绍蛋白质SUMO 化修饰在疾病发生发展中的相关作用。

Protein SUMOylation and disease

ZHENG Quan， CHENG Jin-Ke*

(Department of Biochemistry and Molecular Cell Biology， Shanghai Jiao Tong University School of Medicine， Shanghai 200025， China)

Abstract: Abstract: It has been for more than twenty years to identify protein modification by small ubiquitin-like modifier (SUMOylation). Protein SUMOylation is a reversible process. More than 3 000 peptides have been reported to be conjugated by SUMO in cells. SUMOylation can affect protein function and play a vital role in physiology as well as pathology. In this review， we will focus on roles of protein SUMOylation in pathogenesis.