《生命科学》 2018, 30(3): 327-332
摘 要:摘 要:sRNA 在细菌的生命过程中发挥重要调控作用,可以调节自身基因改变新陈代谢,在不利的宿主环境(pH、温度、氧化物等) 中生存下来,而且越来越多证据表明sRNA 在与宿主细胞相互作用中,能够直接影响宿主基因表达,尤其是免疫基因,降低宿主免疫反应,改变宿主细胞内环境,最终破坏宿主细胞,引起疾病的发生。但目前致病菌sRNA 与宿主相互作用的研究仍处在初级阶段,还没有相关系统综述。现结合国内外最新研究前沿以及实验室相关研究工作,详细论述sRNA 在与宿主相互作用中的具体调控方式,为细菌sRNA 进一步研究提供有益帮助。
Abstract: Abstract: The small regulatory RNA (sRNA) has important regulatory functions in bacteria with 40-500 nucleotides in length. sRNA is involved in regulating cell envelope structure, metabolism, bacterial communication, quorum sensing, biofilm formation and virulence through binding to target bacterial mRNAs or direct interaction with protein targets. Recent study has found sRNA involved in adapting to the host microenvironment and regulating the host gene expression. Considering the importance of sRNA in the whole life cycle of bacteria, we reviewed sRNA roles in bacteria-host interactions, combining with the latest research and our own work. It will be helpful for sRNA research in the future.