《生命科学》 2018, 30(3): 241-247

EV71和CA16研究进展综述

宋　杰，胡雅洁，董少忠*

(中国医学科学院&北京协和医学院医学生物学研究所，云南省重大传染病疫苗研发重点实验室，昆明 650118)

摘　要：摘　要：手足口病(hand-foot and mouth disease， HFMD) 是一种全球性的传染病，其主要病原体为肠道病毒71 型(enterovirus 71， EV71) 和柯萨奇病毒A 组16 型(cosackievirus A 16， CA16)。EV71 与CA16 同属于小核糖核酸(ribonucleic acid， RNA) 病毒科(Picornaviridae) 肠道病毒属(Enterovirus) 肠道病毒A 型(Human enterovirus A) 的成员，两者在病原学、感染和复制特征以及感染导致的临床症状和免疫反应有相似的方面，但也有明显不同的方面。现将对EV71 和CA16 相关的病原学、感染和复制特征以及临床症状和免疫反应研究进行综述。

Summary of EV71 and CA16 research progress

SONG Jie， Hu Ya-Jie， DONG Shao-Zhong*

(Yunnan Key Laboratory of Vaccine Research & Development on Severe Infections Disease， Institute of Medical Biology， Chinese Academy of Medicine Science and Peking Union Medical College， Kunming 650118， China)

Abstract: Abstract: Hand-foot and mouth disease， which was predominantly caused by human enteroviruses， especially enterovirus 71 (EV71) and coxsakievirus A 16 (CA16)， is a global and serious epidemic disease. EV71 and CA16 both belong to the Human enterovirus A (HEV-A) species of the Picornaviridae family. In terms of etiology，infection and replication characteristics， as well as clinical symptoms and immune response， EV71 and CA16 have similar aspects. However， there are also significant differences between the two viruses. In this paper， we will review progress on EV71 and CA16 related etiology， infection and replication characteristics， as well as clinical symptoms and immune response.