《生命科学》 2018, 30(2): 187-195

病毒非编码RNA与肿瘤发生发展

唐飞羽1，何　江1，2 ，李　江1，孙仑泉1，2*

(1 中南大学湘雅医院分子医学研究中心，长沙 410008；2 湖南省分子放射肿瘤学重点实验室，长沙 410008)

摘　要：摘　要：超过12% 的人类肿瘤与病毒密切相关， 如Epstein-Barr virus (EBV)、high-risk human papillomaviruses (HPV)、hepatitis B virus (HBV)、hepatitis C virus (HCV)、Kaposi’s sarcoma herpesvirus (KSHV) 等。 传统观点认为病毒调控细胞恶性转化及肿瘤发生主要与病毒编码蛋白相关，但随着组学和测序技术发展，人们开始认识到病毒非编码RNA 在肿瘤发生发展中的重要性。这些非编码RNA 不翻译为蛋白质，仅在RNA 水平参与对宿主细胞和病毒自身生命活动的多方面调控。现将针对长非编码RNA、短非编码RNA 及microRNA 在肿瘤中的调控进行综述。

Viral noncoding RNAs in virus-associated tumors

TANG Fei-Yu1， HE Jiang1，2， LI Jiang1， SUN Lun-Quan1，2*

(1 Center for Molecular Medicine， Xiangya Hospital， Collaborative Innovation Center for Cancer Medicine， Central South University， Changsha 410008， China; 2 Key Laboratory of Molecular Radiation Oncology Hunan Province， Changsha 410008， China)

Abstract: Abstract: Over 12% of human cancers are closely related to viruses， such as Epstein-Barr virus， high-risk human papillomaviruses， hepatitis B and C viruses， and Kaposi’s sarcoma herpesvirus. It has been well accepted that cellular pathogenicity and tumorigenesis are mainly associated with viral proteins in virus-associated tumors. However， owing to the development of sequencing technologies， now people pay more attention to viral noncoding RNAs (ncRNAs). These ncRNAs regulate cellular physiologic and pathologic processes in a direct way. In this review， we mainly focus on the recent understanding of the long and short ncRNAs as well as microRNAs of the viruses， and discuss their roles in cancer biology of multistep oncogenesis mediated by established human oncoviruses.