《生命科学》 2018, 30(2): 157-168

肿瘤细胞“炎化”与NF-κB信号通路的非编码RNA调控

刘湜桦1，2，管洪宇3，黎孟枫1，2*

(1 中山大学中山医学院微生物系，广州 510080；2 热带病防治研究教育部重点实验室
    (中山大学)，广州 510080；3 中山大学附属第一医院内分泌内科，广州市 510080)

摘　要：摘　要：作为转录因子，NF-κB 通过转录调节基因表达参与肿瘤的发生进展。诸多研究表明，几乎在所有肿瘤中都存在肿瘤细胞内NF-κB 信号通路的持续激活。然而，本来在生理状态下受到严格调控的NF-κB 信号通路在肿瘤细胞中如何持续地被激活，其细胞分子生物学机制尚不清楚。现就简要评述非编码RNA(miRNA 和lncRNA) 对肿瘤细胞内NF-κB 炎性通路的调节及其可能的临床转化意义。

NcRNA regulation of the NF-κB pathway and intratumor-cell activation of inflammatory signaling

LIU Shi-Hua1，2， GUAN Hong-Yu3， LI Meng-Feng1，2*

(1 Department of Microbiology， Zhongshan School of Medicine， Sun Yat-Sen University， Guangzhou 510080， China; 2 Key Laboratory of Tropical Disease Control (Sun Yat-Sen University)， Ministry of Education， Guangzhou 510080， China; 3 Department of Endocrinology， The First Affiliated Hospital of Sun Yat-Sen University， Guangzhou 510080， China)

Abstract: Abstract: Transcription factor NF-κB plays important roles in the development and progression of malignant tumor through regulating the expression of a wide variety of genes. Constitutive activation of NF-κB has been evidenced in many cancer types. While NF-κB signaling pathway is tightly regulated in physiological settings， quite frequently it is constitutively activated in cancer cells， leading the cancer cells to a status we designate as being “inflamized”.The molecular biology mechanisms underlying the deregulated activation of NF-κB signaling， however， remain unclear. In this review， the regulatory role and possible clinical conversion of non-coding RNA (miRNA and lncRNA) in NF-κB signaling pathway in inflammatory tumor cells will be discussed.