《生命科学》 2018, 30(1): 100-106
摘 要：摘 要：p62 是一种多功能蛋白，其蛋白分子包含多个结构域，通过与不同蛋白质结合形成细胞中重要的信号中心，从而调控多种信号通路，影响细胞的生长、衰老，甚至死亡等生理过程。p62 蛋白通过对mTORC1 信号通路的影响在氨基酸信号通路中发挥着关键的调控作用。p62 蛋白是自噬体与底物之间的适配蛋白，在细胞自噬过程中起到分子调节器的作用。p62 蛋白具有质核穿梭功能，在DNA 损伤修复和氧化应激反应中具有重要作用，其异常积累会引起细胞的恶性转变，导致肿瘤的发生。现综述p62 在调节多种信号通路，如自噬、氨基酸感知、凋亡及肿瘤发生等过程中的作用。
Abstract: Abstract: p62 is a multifunctional protein. p62 has multiple domains that mediate its interactions with various binding partners and it serves as a signaling hub for diverse cellular events such as cell growth， aging and even death. p62 also plays a key regulatory role in the amino acid sensing by regulating mTORC1 signaling pathway. p62 acts as an adapter between the autophagosome and it’s substrates， functioning as a molecular regulator in autophagy.In addition， p62 can shuttle between nuclear and cytoplasm and plays an important role in DNA damage repair and oxidative stress response. The abnormal accumulation of p62 may lead to the malignant transformation of cells， which finally promote the occurrence of the tumor. In this review， we discuss the current knowledge about p62 in various signaling pathways， such as autophagy， apoptosis and tumorigenesis.
