《生命科学》 2018, 30(1): 74-81

SIRT1介导的K-Ras、FoxOs和DLC1的表达及翻译后修饰调控癌细胞的增殖和凋亡

刘亭亭，柴荣飞，郑兆娣，李国荣*

(山东师范大学生命科学学院，济南 250014)

摘　要：摘　要：SIRT1 是一种NAD+ 依赖的组蛋白去乙酰化酶，可通过其去乙酰化酶活性介导下游蛋白，如K-Ras、FoxOs 和DLC1 的翻译后修饰来调节细胞增殖和细胞凋亡。在体外培养的癌细胞、异种移植癌细胞的裸鼠或是转基因小鼠中，K-Ras 的乙酰化、FoxOs 的乙酰化和磷酸化及DLC1 的磷酸化对癌细胞的增殖或凋亡均发挥双重作用，研究SIRT1 介导的翻译后修饰对于癌症的治疗具有重要的意义。

Expression and post-translational modifications of K-Ras， FoxOs and DLC1    mediated by SIRT1 regulate proliferation and apoptosis of cancer cells

LIU Ting-Ting， CHAI Rong-Fei， ZHENG Zhao-Di， LI Guo-Rong*

(College of Life Science， Shandong Normal Unversity， Jinan 250014， China)

Abstract: Abstract: SIRT1 is a NAD+-dependent histone deacetylase， it modifies post-translational modifications of downstream proteins such as K-Ras， FoxOs and DLC1 to regulate proliferation and apoptosis. However， acetylation of K-Ras， phosphorylation and acetylation of FoxOs， and phosphorylation of DLC1 have been reported to have dual effects on proliferation and apoptosis in several cancer cell lines， orthotopic cancers of nude mice or transgenic mice. Thus， studies aimed at highlighting SIRT1-mediated post-translational modifications are essential for cancer therapy.