《生命科学》 2018, 30(1): 48-55

长链非编码RNA在肺癌中的研究进展

席姣姣 ，颜景斌*

(上海市儿童医院，上海医学遗传研究所，上海交通大学附属儿童医院，卫生部医学
    胚胎分子生物学重点实验室， 上海市胚胎与生殖工程重点实验室，上海 200040)

摘　要：摘　要：长链非编码RNAs (long noncoding RNAs， lncRNAs) 是一种长度大于200 nt，无编码蛋白质功能的RNA 分子。lncRNAs 在转录和转录后不同层面调控基因的表达，进而参与细胞的生长、分化和凋亡等生命过程。近年来的研究显示，异常表达的lncRNAs 与肺癌的发生发展密切相关，有望成为肺癌诊断中有效的生物标志物。因此，对lncRNAs 的深入研究有助于阐明肺癌发生发展的分子机制，为肺癌的诊断和治疗提供新靶点。

Progress of long noncoding RNAs in the lung cancer

XI Jiao-Jiao， YAN Jing-Bin*

(Shanghai Key Laboratory of Embryo and Reproduction Engineering， Key Laboratory of Embryo Molecular Biology of Ministry of Health， Shanghai Institute of Medical Genetics， Shanghai Chlidren’s Hospital， Shanghai JiaoTong University， Shanghai 200040， China)

Abstract: Abstract: Long noncoding RNAs (lncRNAs) are defined as transcripts greater than 200 nucleotides in length， that lack significant protein-coding capacity. LncRNAs can regulate gene expression at transcriptional and posttranscriptional levels， and participate in cell growth， differentiation and apoptosis. Recent studies demonstrated that anomalous expression of lncRNAs was closely associated with the tumorigenesis and progression of lung cancer， which may be a potential efficient biomarker for clinical diagnosis. Therefore， further studies of lncRNAs will be helpful to elucidate molecular mechanisms of lung cancer pathogenesis， and also may provide novel diagnostic and therapeutic targets for lung cancer.