《生命科学》 2005, 17(1): 10-14

非甾体抗炎药物的研究应用现状

宣云遐，王明伟^*

中国科学院上海生命科学研究院药物研究所，国家新药筛选中心，上海　201203

摘　要：摘　要：非甾体抗炎药物种类繁多，用途广泛，占有巨大的市场份额。最近默克公司对罗非昔布的全球撤药事件告诫人们，必须科学和谨慎地看待这类药物的发展，通过深入的临床研究和实践总结来开发更为安全、经济合理的新药，以提高和改善患者的生命质量。
关键词：非甾体抗炎药；环氧合酶；脂氧合酶；抑制剂

Current status of non-steroidal anti-inflammatory drugs

XUAN Yun-Xia， WANG Ming-Wei^*

The National Center for Drug Screening， Shanghai Institute of Materia Medica， Shanghai Institutes for Biological Sciences， Chinese Academy of Sciences， Shanghai 201203， China

Abstract: Abstract: Non-steroidal anti-inflammatory drugs（NSAIDs）are of a large variety， widespread use and significant market presence. Recent worldwide withdrawal of Vioxx by Merck indicates that development of NSAIDs must be guided by sciences and with caution. Extensive clinical evaluation and continuous feedback from practices are essential to discover novel and more safe， efficacious， economical and rational NSAIDs， with an ultimate goal of lifting and improving the life quality of patients.
Key words: non-steroidal anti-inflammatory drugs; cyclooxygenase; lipoxygenase; inhibitors