《生命科学》 2018, 30(1): 9-19

神经营养因子在阿尔茨海默病中的作用及应用现状

乌汉其木格*，敖登其木格，张　文，奥东塔娜，斯琴塔娜

(内蒙古自治区国际蒙医医院，呼和浩特 010065)

摘　要：摘　要：神经营养因子是一类机体内分泌的，为神经元发育、生长及分化所必需的蛋白质。在整个生命过程中，神经营养因子对中枢及周围神经系统中神经元功能特性的表达、维持突触的生长及可塑性、防止神经元受损及凋亡及改善已受损神经元修复均具有重要的调控作用。结合神经生长因子与脑源性神经生长因子研究现状，主要介绍神经生长因子与脑源性神经生长因子在阿尔茨海默病中的作用及机理研究进展，总结神经营养因子在阿尔茨海默病临床应用的现状，最后分析预防和治疗阿尔茨海默病新手段的研究方向。

Implications of neurotrophins in the pathogenesis and therapy for Alzheimer's disease

Wuhanqimuge*， Aodengqimuge， ZHANG Wen， Aodongtana， Siqintana

(Inner Mongolia International Mongolian Hospital， Hohhot 010065， China)

Abstract: Abstract: Neurotrophins are a family of secreted proteins necessary for the growth， survival and differentiation of neurons. They play essential roles in the central and peripheral nervous system by regulating diverse physiological functions of neurons， supporting the growth of axon and plasticity of neurons， protecting neurons from damage and apoptosis and improving the repair of damaged neurons throughout the entire life. Here， we first focused on the recent advances of the roles and mechanisms of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in Alzheimer's disease (AD)， then summarized the status quo of clinical applications of neurotrophins in AD， finally discussed the future directions for the development of new therapies for AD.