《生命科学》 2017, 29(11): 1174-1184

无脊椎动物免疫记忆研究进展

曾新洋1，张子平2，王艺磊1*

(1 集美大学水产学院，农业部东海海水健康养殖重点实验室，厦门 361021；2 福建农林大学动物科学学院，福州 350002)

摘　要：摘　要：无脊椎动物没有适应性免疫是目前流行的观点。然而，越来越多的研究表明，无脊椎动物在遭遇病原微生物的重复侵染时存在类似脊椎动物免疫记忆的现象，被称作天然性免疫记忆或免疫致敏。首先回顾了传统的免疫记忆及其发生机制，之后介绍了无脊椎动物免疫记忆现象及其研究进展，总结了无脊椎动物免疫记忆的几种可能发生机制，并对将来的研究提出了一些初步的设想。

Progress in immunological memory of invertebrates

ZENG Xin-Yang1， ZHANG Zi-Ping2， WANG Yi-Lei1*

(1 Key Laboratory of Healthy Mariculture for the East China Sea， Ministry of Agriculture， College of Fisheries， Jimei University， Xiamen 361021， China; 2 College of Animal Science， Fujian Agriculture and Forestry University， Fuzhou 350002， China)

Abstract: Abstract: The current opinion is that invertebrates do not have adaptive immunity. However， more and more studies have shown that invertebrates have a similar phenomenon to vertebrate immune memory when they are infected with pathogenic microorganisms repeatedly， which is known as “specific memory within innate immune systems” or “immune priming”. In this paper， we firstly reviewed the occurrence and mechanism of traditional immunological memory， then introduced the phenomenon and progress in the immune priming in invertebrates， summarized several kinds of possible mechanisms for invertebrate immune memory， and finally provided some preliminary ideas for future research.