《生命科学》 2017, 29(11): 1161-1166

5-HT受体乙酰化修饰在阿尔茨海默病患者精神行为症状发生发展中的作用研究

赵红云1，2#，曾　燕1#*，董红心1

(1 武汉科技大学医学院脑与认知功能研究所，武汉 430065；2 杭州市余杭区第五人民医院康复科，杭州 311100)

摘　要：摘　要：痴呆合并精神行为症状(behavioral and psychological symptoms of dementia， BPSD) 包括精神运动性兴奋、心境障碍( 焦虑、抑郁和淡漠) 和精神症状 ( 妄想和幻觉) 等，是阿尔茨海默病(Alzheimer’s disease，AD) 患者的主要并发症，伴随着90% 的AD 患者。随着病程进展和认知功能下降，BPSD 症状的严重程度加深，成为AD 患者住院的首位原因。然而，AD 患者并发BPSD 的机制还不清楚，也缺乏有效的治疗。最近的研究推测，5- 羟色胺(5-hydroxytryptamine， 5-HT) 系统可能参与BPSD 的发生和发展。现对5-HT 系统在BPSD 发病和症状恶化过程中的作用进行综述，重点探讨了5-HT 受体乙酰化修饰在其中的可能作用以及去乙酰化酶抑制剂的治疗潜力，以期深入理解AD 患者并发BPSD 的机制。

Research progress in roles of 5-hydroxytryptamine receptor histone acetylation in regulation of behavioral and psychological symptoms of Alzheimer’s disease

ZHAO Hong-Yun1，2#， ZENG Yan1#*， DONG Hong-Xin1

(1 Brain and Cognitive Function Research Institute， Wuhan University of Science and Technology， Wuhan 430065， China; 2 The Department of Rehabilitation， the Fifth People's Hospital of Yuhang District， Hangzhou 311100， China)

Abstract: Abstract: Behavioral and psychological symptoms of dementia (BPSD)， including psychomotor excitement， mood disturbances (e.g. anxiety， depression， and the loss of motivation)， and psychosis (e.g. delusion and hallucination) are common complications that occur in more than 90% of Alzheimer’s disease (AD) patients. Increased severity of BPSD is significantly accelerated with disease progression and remains the main reason for hospitalization， significantly affecting the quality life of both patients and caregivers. However， the mechanisms underlying BPSD are not known， and there is no targeted or widely effective treatment strategy available. Recent studies suggest that the 5-hydroxytryptamine (5-HT) may be involved in the initiation and progression of BPSD. In order to further understand the mechanism of AD in patients with BPSD， this article reviews the role of 5-HT in the pathogenesis of BPSD and the deterioration of symptoms. A particular focus is placed on the implication of 5-HT receptors histone modifications in BPSD pathogenesis and antipsychotic efficacy.