《生命科学》 2017, 29(11): 1156-1160

自噬在非酒精性脂肪肝合并糖尿病中的作用

陈佳意，习　阳，步世忠*

(宁波大学医学院糖尿病研究中心，宁波 315000)

摘　要：摘　要：在一系列应激状态下，自噬会作为一种适应性免疫应答反应出现，是细胞的自我保护机制之一。研究表明，在非酒精性脂肪肝病的早期阶段，自噬增加有助于肝内脂质降解，缓解病情；而在后期阶段，自噬增加却会加剧病情发展。胰岛素抵抗可能会促使非酒精性肝病发生糖尿病，β 细胞功能缺陷和胰岛素抵抗是2 型糖尿病发病的两种最主要病理生理机制。多项研究证实，自噬增加能提高胰岛素敏感性，对维持胰岛β 细胞的结构、数量以及功能也有重要作用。旨在阐述自噬在非酒精性脂肪肝病以及非酒精性脂肪肝病合并糖尿病治疗中的作用。

The role of autophagy in non-alcoholic fat liver disease with type 2 diabetes

CHEN Jia-Yi， XI Yang， BU Shi-Zhong*

(Diabetes Research Center， School of Medicine ，Ningbo University，Ningbo 315000， China)

Abstract: Abstract: As an adaptive immune response occurring under a series of stress states， autophagy is one of the cellular self-protection mechanisms. Many studies have shown that increased autophagy would degrade liver lipid and alleviate the disease in early stages of non-alcoholic fat liver disease (NALFD). However in later stages， increased autophagy exacerbated NALFD development. Insulin resistance may lead NALFD to the diabetes. β-cell dysfunction and insulin resistance are the two most important pathophysiological mechanisms of type 2 diabetes. A number of studies confirmed that autophagy increased insulin sensitivity. Meanwhile， autophagy played an important role in maintaining the structure， mass， and function of pancreatic β-cells. This article reviewed the role of autophagy in NAFLD treatment and non-alcoholic fatty liver disease with diabetes mellitus.