《生命科学》 2017, 29(11): 1149-1155

miR-17-92、自噬在肿瘤中的研究进展

张新菊1，张笑天2，马中良1*

(1 上海大学生命科学学院非编码RNA与癌症实验室，上海 200444；2 上海交通大学附属第六人民医院骨科，上海 200233)

摘　要：摘　要：microRNA (miRNA) 是一类在转录后水平调控目的基因表达的功能性小RNA 分子。miR-17-92 基因簇是一个高度保守的基因簇，编码6 个miRNAs，分别为：miR-17、miR-18a、miR-19a、miR-19b-1、miR-20a 和miR-92a。细胞自噬(autophagy) 是将细胞内受损、变性或衰老的蛋白质以及细胞器运输到溶酶体进行消化降解的过程。miRNA 的异常表达可影响自噬水平，从而影响肿瘤的发生发展。研究证明miR-17-92 基因簇与细胞自噬及肿瘤的发生密切相关，有望成为具有潜在价值的肿瘤标志物或肿瘤治疗的新靶点。现对miR-17-92 基因簇与细胞自噬和肿瘤的关系进行综述。

miR-17-92 cluster and autophagy in cancer

ZHANG Xin-Ju1， ZHANG Xiao-Tian2， MA Zhong-Liang1*

(1 Laboratory for non-coding RNA & Cancer， School of Life Sciences， Shanghai University， Shanghai 200444， China; 2 Department of Orthopaedics， Shanghai Sixth People’s Hospital， Shanghai Jiaotong University， Shanghai 200233， China)

Abstract: Abstract: MiRNAs are small RNA molecules that regulate the expression of target genes at the post transcriptional level. MiR-17-92 is a highly conserved gene cluster encoding 6 miRNAs: miR-17， miR-18a， miR-19a， miR-19b-1， miR-20a and miR-92a. Autophagy is the process of digestion and degradation of proteins， and organelles that are damaged， denatured or aged. Studies have reported that the abnormal expression of miRNA is sufficient to affect autophagy， thus affecting the development of tumor. MiR-17-92 cluster is closely related to autophagy and tumor development， and it is promising to be a potential tumor marker or a new target for tumor therapy. Here， we review the progress of miR-17-92 gene cluster in autophagy and tumor.