《生命科学》 2017, 29(11): 1133-1140
摘 要：摘 要：Bcl2 相关永生基因3(BAG3) 被鉴定为抗凋亡和前自噬因子，包含BAG、WW 和PXXP 三个结构域。BAG3 与多种蛋白相互作用，被多种信号激活，又能激活多种信号通路，调控多种生理和病理过程，提示开发其特异性抑制剂可能为肿瘤的化学治疗提供候选药物，而开发其特异性激活剂可能为肌肉及神经退行性疾病的防治提供候选药物。现对人源BAG3 的结构特征、相互作用蛋白、信号通路及生物学功能进行综述。
Abstract: Abstract: Bcl2-associated athanogene 3 (BAG3) contains BAG， WW and PXXP domains， and plays important functions in the anti-apoptotic and pro-autophagic effects. BAG3 is a co-chaperone of the heat shock protein (Hsp) 70 and is involved in the regulation of various physiological and pathological processes. BAG3 is not only activated by several signaling pathways， but also activates a number of signaling pathways through interacting with a variety of proteins， indicating that the development of BAG3 specific inhibitors or activators may provide the novel candidate drugs for the treatment of tumors and degenerative diseases， including muscle and nerves. In this review， we discuss the structural features， interacting proteins， signaling pathways and biological functions of human BAG3.
