《生命科学》 2005, 17(1): 76-81

乳腺生物反应器的研究现状和产业化前景

王庆忠，李国荣，尹　昆，张会亮，李云龙sup>*

山东师范大学生命科学学院，济南 250014

摘　要：摘　要：转基因动物乳腺生物反应器是伴随转基因动物技术而发展起来的一项高新生物技术。利用这项技术，我们可以从动物乳汁中源源不断地获取用于医疗或保健目的的有生物活性的基因产物。这是一种全新的蛋白质生产模式，它将成为许多国家的重要支柱产业之一。本文介绍了乳腺生物反应器的基本概念和基本原理；概述了制备过程中的目的基因选择、载体构建、转基因等技术环节的研究现状；分析了乳腺生物反应器的优势及存在的问题，并就其产业化前景进行了展望。
关键词：转基因动物；乳腺生物反应器；表达载体；转基因技术

The study actuality and industrial prospects of mammary gland bioreactor

Wang Qing-Zhong， Li Guo-Rong， Yin Kun， Zhang Hui-Liang， Li Yun-Long^*

School of Life Science， Shandong Normal University， Jinan 250014， China

Abstract: Abstract: Transgenic animal抯 mammary gland bioreactor that was developed from animal transgenic technology is a new high-biotechnology. Using this technology， we can obtain the active gene products from milk constantly for the purpose of medical treatment and health care. This is a new-type protein-producing mode and will become one of the major industrial fields in many countries. In this paper， the basic concept and basic principle of mammary gland bioreactor was introduced; the selection of exogenous gene， the construction of expression vector， transgenic methods and so on in the course of making mammary bioreactor were summarized; the advantages and the problems of it at present were also reviewed; the industrial prospects in the future were discussed.
Key words: transgenic animal; mammary gland bioreactor; expression vector; transgenic technology