《生命科学》 2017, 29(9): 908-915
摘 要：摘 要：Hippo 信号通路是最早在果蝇(Drosophila) 中发现的，在进化上高度保守，具有调控细胞增殖与凋亡作用的一条关键信号转导通路。在哺乳动物中，Hippo 信号通路在调控细胞增殖、细胞死亡、细胞分化和肿瘤生成等生物学过程中有着十分重要的作用。近年来，Hippo 信号通路在免疫系统以及多种功能性免疫细胞中发挥的重要作用逐渐成为该领域的研究热点，特别是Hippo 信号通路各成员在免疫细胞应对病毒、细菌入侵或肿瘤发生以及维持自身稳态过程中发挥着重要的作用。因此，深入了解Hippo 信号通路各成员对多种功能性免疫细胞的调控机制，有助于绘制新的免疫系统调控网络，阐明各类免疫系统相关疾病的发病机制，期望为诊断、治疗和预防相关疾病提供新的治疗策略或靶点。
Abstract: Abstract: The Hippo signaling pathway was first discovered as a result of genetic studies of tissue growth in Drosophila to mediate organ size control. This pathway is evolutionally conserved and the orthologs to its main components have been identified in mammals respectively. The Hippo signaling pathway consists of a core kinase cascade which plays central roles in the Hippo pathway controlling the cell proliferation， apoptosis， and differentiation during development and tumorigenesis. In recent years， numerous studies reported that Hippo signaling also plays diverse and important roles in the immune system. In this review， we summarize recent findings related to the new function of core components of the Hippo signaling pathway in immune regulation. A better understanding of how Hippo signaling regulated the immune function will help us to draw a novel immuneregulatory network and provide a new treatment strategies or targets for immune-related diseases.
