《生命科学》 2017, 29(9): 898-907
摘 要：摘 要：炎症小体在炎症相关疾病的发生发展中发挥重要作用，其中NLRP3 炎症小体能够被多种病原相关分子模式(pathogen-associated molecular patterns， PAMPs) 和损伤相关分子模式(damage-associated molecular patterns， DAMPs) 激活，进而活化caspase-1，释放成熟形式的IL-1β 和IL-18，引起机体的炎症反应，并参与多种疾病的发生发展，包括2 型糖尿病、痛风、动脉粥样硬化、神经退行性疾病、肿瘤、炎症性肠病等。因此，研究NLRP3 炎症小体的作用机制不仅有助于加深对炎症性疾病发生发展的认识，也为寻找此类疾病的潜在治疗靶点提供了新的思路。就NLRP3 炎症小体在炎症相关疾病中的研究进展作一综述。
Abstract: Abstract: Inflammasomes play an important role in the initial and progressive process among various inflammation-related diseases. The NLRP3 inflammasome is vital in the innate immune system. It could recognize series of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) and be activated. Activated NLRP3 inflammasome stimulates caspase-1 activation that triggers maturation and secretion of pro-inflammatory cytokines， including interleukin-1β and interleukin-18. A number of recent landmark studies revealed that inflammation-related diseases such as type 2 diabetes， gout， atherosclerosis， neurodegenerative diseases， cancer， inflammatory bowel disease (IBD) are closely related with NLRP3 inflammasome. Thus， study on the NLRP3 inflammasome in inflammation-related diseases not only expands our understanding on these diseases， but also provides a potential therapeutic target for these diseases. Here we review the recent studies on the pathological contributions of NLRP3 inflammasome in various inflammation-related diseases.
