《生命科学》 2017, 29(9): 873-882

炎症性肠病的发病机理与免疫治疗的研究进展

郭雪坤，胡小玉*

(清华大学医学院，清华免疫学研究所，北京 100084)

摘　要：摘　要：炎症性肠病(inflammatory bowel diseases， IBDs) 是一组慢性、复发性、炎症性肠道紊乱疾病，其典型特征为肠炎和上皮损伤。正常情况下，肠道稳态的维持依赖于肠道微生物、肠道上皮系统和免疫系统三者之间的相互作用。目前认为，肠道稳态的破坏可能是IBD 发病的原始基础和持续性发病的诱因。现着重从肠道微生物、肠道上皮屏障和肠道固有免疫这三方面对IBD 的发病机理研究进展进行综述，并介绍在IBD 免疫治疗方面的一些研究进展。

The pathogenesis and immunotherapies of inflammatory bowel disease

GUO Xue-Kun， HU Xiaoyu*

(Institute for Immunology and School of Medicine， Tsinghua University，

Abstract: Abstract: Inflammatory bowel diseases (IBDs) are chronic relapsing disorders of the intestinal tract that are pathologically characterized by intestinal inflammation and epithelial injury. Under physiological conditions， intestinal homeostasis is maintained by the complex interactions between microbiota， intestinal epithelium and the host immune system. It is now evident that breakdown of intestinal homeostasis contributes to initial pathogenesis as well as relapsing of IBD. In this review， we summarized the latest research progresses regarding pathogenesis of IBD from the following three perspectives: microbiota， intestinal epithelial barrier and intestinal innate immunity. In addition， we also discussed the latest studies related to IBD immunotherapies.