《生命科学》 2017, 29(9): 833-844

Treg细胞功能调节与抗肿瘤免疫治疗

赵彬彬1，伊　刚2，王帅威2，李　斌3，4*

(1 中国科学院上海巴斯德研究所分子病毒与免疫重点实验室，上海 200031；2 上海大学生命科学学院上海市能源作物育种及应用重点实验室，上海 200444；3 上海交通大学医学院上海市免疫学研究所，上海 200025；4 上海交通大学医学院免疫学与微生物学系，上海 200025)

摘　要：摘　要：CD4+CD25+FOXP3+ 调节性T 细胞(Treg) 负责维持体内免疫稳态和免疫耐受，转录因子FOXP3 对于其发育分化及生理功能至关重要。 FOXP3 功能在转录、翻译和翻译后修饰等多个层次被精细调控。Treg在肿瘤微环境中聚集而介导肿瘤的免疫逃逸，减少微环境中的Treg 细胞数量并降低其活性，有助于促进机体的抗肿瘤免疫反应。深入研究不同组织及不同炎症微环境下Treg 功能调节机制及其细胞特异性表面标志物，将为肿瘤免疫治疗提供新思路和新策略。

The functional regulation of Treg and its role in anti-tumor immunotherapy

ZHAO Bin-Bin1， YI Gang2， WANG Shuai-Wei2， LI Bin3，4*

(1 Key Laboratory of Molecular Virology & Immunology， Unit of Molecular Immunology，
    Institut Pasteur of Shanghai， Chinese Academy of Sciences， Shanghai 200031， China;
    2 Shanghai Key Laboratory of Bio-energy Crops， College of Life Science， Shanghai University， Shanghai 200444， China; 3 Shanghai Institute of Immunology， Shanghai JiaoTong University School of Medicine， Shanghai 200025， China; 4 Department of Immunology and Microbiology， Shanghai JiaoTong University School of Medicine， Shanghai 200025， China)

Abstract: Abstract: Regulatory T (Treg) cells play a key role in the maintenance of immune homeostasis and tolerance and the transcription factor FOXP3 is essential for its development and differentiation. The function of FOXP3 is delicately regulated at multiply levels， including transcriptional， translational and post-translational modification. Regulatory T cells accumulate in tumor microenvironment and play a role in promoting tumor escape. The antitumor response could be greatly improved by elimination and activity inhibition of Tregs at the tumor microenvironment. Understanding the mechanism of functional regulation and identifying special markers of Tregs will stimulate new ideas and directions for anti-tumor immunotherapy.