《生命科学》 2017, 29(8): 773-778

维生素B3与帕金森病的防治

安竹燕1，李清华1，柯尊记1，2*

(1 桂林医学院广西脑与认知神经科学重点实验室，桂林 541004；2 上海中医药大学生物
    化学教研室，神经科学研究中心，上海市健康辨识与评估重点实验室，上海 201203)

摘　要：摘　要：帕金森病(PD) 是以运动功能失调为主要表现的神经退行性疾病，其病理特征是黑质致密部多巴胺能神经元的丢失和路易氏小体的形成。线粒体能量供应障碍和氧化应激在PD发生与发展过程中起重要作用，抗氧化和改善线粒体功能的物质可延缓PD 的发展。维生素B3 是体内氧化还原体系的重要组分，参与抗氧化、抗炎、促进自噬以及维护神经元正常结构和功能，提示补充维生素B3 可能是延缓PD 的方法之一。

Vitamine B3 and Parkinson’s disease

AN Zhu-Yan1， LI Qing-Hua1， KE Zun-Ji1，2*

(1 Guangxi Key Laboratory for Brain and Cognitive Neurosciences， Guilin Medical College， Guilin 541004， China; 2 Department of Biochemistry， Center for Neurosciences， Shanghai Key Laboratory of Health Identification and Assessment， Shanghai University of Traditional Chinese Medicine， Shanghai 201203， China)

Abstract: Abstract: Parkinson’s disease (PD) is a degenerative disorder of the central nervous system that mainly affects the motor system. The early symptoms of PD are shaking， rigidity， slowness of movement， and difficulty with walking. The primary symptoms of PD result from the death of dopamine-secreting cells in the pars compacta region of the substantia nigra. The histopathological feature of the substantia nigra shows neuronal loss and Lewy bodies formation in the remaining nerve cells， which is a key pathological feature of PD. Oxidative stress， mitochondrial disfunction and protein aggregation play a role in neuronal death in PD. Antioxidants， mitochondrial nutrients and anti-inflammatory drugs show protective effects. Vitamin B3 complex includes nicotinamide and niacin， which are precursors of the coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) in vivo. NADP and NAD are coenzymes for many dehydrogenases， participating in many hydrogen transfer processes. Vitamin B3 also shows antioxidative， anti-inflammatory， and mitochondria protecting effects with activation of mitophagy. The studies suggest that vitamin B3 complex may slow down the development of PD.