《生命科学》 2017, 29(7): 682-686

肠道微生物与动脉粥样硬化

王则能1*，颜　彦2

(1 克利夫兰医学中心细胞与分子医学系，美国俄亥俄州克利夫兰 44122；2 复旦大学附属中山医院心内科，上海 200032)

摘　要：摘　要：肠道微生物通过其代谢产物参与一些生理及病理过程。主要介绍了几类与动脉粥样硬化相关的代谢产物，包括胆汁盐、短链脂肪酸、原儿茶酸、氧化三甲胺、脂多糖，阐述其如何影响动脉粥样硬化的进程，并讨论了通过降低一些有害代谢产物来预防与治疗动脉粥样硬化性心血管疾病的可行性。

Gut microbiota and atherosclerosis

WANG Ze-Neng1*， YAN Yan2

(1 Department of Cellular & Molecular Medicine， Cleveland Clinic， Cleveland， Ohio 44122， USA; 2 Department of Cardiovascular Medicine， Zhongshan Hospital， Fudan University， Shanghai 200032， China)

Abstract: Abstract: Gut microbiota is involved in some physiological processes and disease pathogenesis mediated by metabolites. This article introduced several metabolites， including bile salts， short chain fatty acids， protocatechuic acid， trimethylamine N-oxide and lipopolysaccharide as well， which are associated with atherosclerosis progression. In addition， the possibility on decreasing atherosclerotic cardiovascular disease frequency by inhibition of the production of harmful metabolites was also discussed.