《生命科学》 2017, 29(7): 636-643

微生物组学与肠道肿瘤

陈慧敏，房静远*

(上海交通大学医学院附属仁济医院消化科，上海市消化疾病研究所，上海 200001)

摘　要：摘　要：肠道肿瘤的发病是宿主、环境等多因素共同作用的结果。宿主与其体内生活的肠道微生物有着密不可分的互利共生关系。随着高通量测序等研究技术的进一步成熟，肠道微生态的功能、组成以及与肠道肿瘤发生、发展、诊治间的关系日趋明朗。确定的和肿瘤相关微生物的异质性可能被开发为筛选肠道肿瘤风险的有力工具，而对菌群的干预和改变可能成为肠道肿瘤预防和治疗策略的重要环节之一。

Microbiomics and intestinal tumors

CHEN Hui-Min， FANG Jing-Yuan*

(Division of Gastroenterology and Hepatology， Renji Hospital， School of Medicine，
    Shanghai Jiao Tong University， Shanghai Institute of Digestive Disease， Shanghai 200001， China)

Abstract: Abstract: Both host and environmental factors contribute to the intestinal tumors development. The intestinal microbiota (IM) plays a significant role in the maintenance of good health in the host. With the development of high-throughput sequencing technology on IM research， the relationship between the intestinal microorganisms and their metabolites， and the development， diagnosis and treatment of colorectal cancer (CRC) become much clearer. Determining the tumor-associated microbial heterogeneity could be a powerful tool for CRC screening. Also， microbial manipulation and microbially-driven cancer immunotherapy could be a potential way to influence host health， prevent and treat CRC.