《生命科学》 2017, 29(7): 624-629

人体微生态与感染性疾病的研究进展

石　鼎，李兰娟*

(浙江大学医学院附属第一医院传染病诊治国家重点实验室；感染性疾病诊治协同创新中心，杭州 310003)

摘　要：摘　要：近年来，人体微生态研究得到了国内外专家学者的广泛关注。研究表明，微生态系统就像人体的一个重要生理功能“器官”，是人类适应环境生存、健康、遗传、疾病和衰老的主导者之一，而且是药物代谢、微生物耐药的重要载体。许多感染性疾病的发生、发展和恶化都与人体微生态系统密切相关。主要从各种感染性疾病体内微生物组变化入手，旨在探讨人体微生态在感染性疾病发生发展中的重要作用，及其在未来感染性疾病精准医疗中的突破性意义。

Research advances in the human microbiota and infectious diseases

SHI Ding， LI Lan-Juan*

(State Key Laboratory for Diagnosis and Treatment of Infectious Diseases，
    The First Affiliated Hospital， School of Medicine， Zhejiang University;
    Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases， Hangzhou 310003， China)

Abstract: Abstract: In recent decades， more and more attention has been abstracted by the human microbiome and its role in both health and disease. It was reported that the human microbiome， which can be looked as a new organ， played key roles in maintaining our immune systems， contributing to the digestion of our food， acting as a first line of defense against pathogens and an important carrier of drug metabolism and microorganism resistance. The human microbiome is closely related with the occurrence， development and deterioration of many infectious diseases. In this review， we will first sum up alterations of human microbiome in infectious diseases， and then discuss the relationship between human microbiome and infectious diseases， and finally predict the potential effect of human microbiome on precision medicine.