《生命科学》 2017, 29(6): 527-533

亮氨酰-tRNA合成酶在人类疾病治疗中的应用

龙　韬1，2，刘如娟1，2*，王恩多1，3*

(1 中国科学院上海生物化学与细胞生物学研究所，分子细胞科学卓越创新中心，国家分子生物学重点实验室，上海 200031；2 中国科学院大学，北京 100864；3 上海科技大学生命科学与技术学院，上海 201210)

摘　要：摘　要：氨基酰-tRNA 合成酶是蛋白质合成过程中的关键酶，广泛参与细胞信号转导、免疫、发育以及疾病等复杂的生理过程。而亮氨酰-tRNA 合成酶作为其中的一员，由于对其经典和非经典功能的研究比较透彻，因而受到了药物研发人员的青睐。现综述了亮氨酰-tRNA 合成酶应用于抗病原菌感染和抗肿瘤等方面的研究进展和治疗前景。

The application of leucyl-tRNA synthetase in the treatment of human diseases

LONG Tao1，2， LIU Ru-Juan1，2*， WANG En-Duo1，3*

(1 State Key Laboratory of Molecular Biology， CAS Center for Excellence in Molecular Cell Science， Shanghai Institute of Biochemistry and Cell Biology， Chinese Academy of Sciences， Shanghai 200031， China; 2 University of Chinese Academy of Sciences， Beijing 100864， China; 3 School of Life Science and Technology， Shanghai Technology University， Shanghai 201210， China)

Abstract: Abstract: Aminoacyl-tRNA synthetase plays a key role in protein synthesis. Recently， those enzymes have been reported to involve in many complicated physiological process such as cell signaling， immune response， development and disease. As a member of them， leucyl-tRNA synthetase has been well studied in its canonical and noncanonical functions and gets the favour of drug researchers. This study summarizes the application of leucyltRNA synthetase in anti-infection and anti-tumor.