《生命科学》 2017, 29(5): 507-513

微小RNAs在阿尔茨海默病Aβ沉积和Tau磷酸化中的作用

赵娟娟#，岳东旭#，褚风云，郭萌萌，徐　林*

(遵义医学院免疫学教研室，遵义 563000)

摘　要：摘　要：阿尔茨海默病(AD) 是最常见的中枢神经系统退行性疾病，主要临床表现为进行性认知功能障碍和行为损伤。近年研究显示，微小RNAs (miRNAs) 在以AD 为代表的中枢神经系统疾病病变过程中发挥了重要调控作用。现综述miRNAs 在AD 发病的关键病理特征——Aβ 的沉积和Tau 磷酸化中的调节作用，以期对AD 发病机制的认识和诊治新策略的开发提供帮助。

The effect of microRNAs on Aβ deposition and Tau phosphorylation in Alzheimer's disease

ZHAO Juan-Juan#， YUE Dong-Xu#， CHU Feng-Yun， GUO Meng-Meng， XU Lin*

(Department of Immunology， Zunyi Medical College， Zunyi 563000， China)

Abstract: Abstract: Alzheimer's disease (AD)， with main clinical features of progressive impairment in cognitive and behavioral functions， is the most common degenerative disease of the central nervous system. Recent literatures documented that microRNAs (miRNAs) played important roles in the pathological progression of AD， the representative for central nervous system diseases. This article reviews the regulatory role of miRNAs in both Aβ deposition and Tau phosphorylation， two key pathological characters in the pathology of AD， which might be helpful for the understanding of pathogenesis and development of new strategies of diagnosis and treatment.