《生命科学》 2017, 29(5): 489-494

雌激素受体在甲状腺癌中作用的研究进展

宋诗平1，赵　越2，王春玉2*

(1 中国医科大学七年制，沈阳 110122；2 中国医科大学基础医学院，卫生部细胞生物学重点
    实验室，教育部医学细胞生物学重点实验室，染色质生物学研究室，沈阳 110122)

摘　要：摘　要：近年来，越来越多的研究报道了雌激素受体在甲状腺癌发生发展过程中的作用。与正常甲状腺组织和结节性增生组织相比，不同亚型的雌激素受体在甲状腺癌中的表达有不同的改变：乳头状甲状腺癌中雌激素受体的表达与Ki67、突变型P53 和VEGF 这些重要肿瘤标志物有关；ERα 与IQGAP1 相互作用促进甲状腺癌进展；ERα 在甲状腺癌中上调Hsp27 表达，等等。这些研究结果确定了雌激素受体对甲状腺癌增殖、侵袭和转移等病理过程的影响，但不同亚型的雌激素受体对甲状腺癌影响尚不完全明确。现就雌激素受体在甲状腺癌中的相关研究进行综述。

Expression of different estrogen receptors relates to thyroid carcinoma

SONG Shi-Ping1， ZHAO Yue2， WANG Chun-Yu2*

(1 Seven-year Postgraduate， China Medical University， Shenyang 110122， China;
    2 Laboratory of Chromatin Biology， Department of Cell Biology， Key Laboratory of Public Health of China， Department of Medical Cell Biology of Ministry of Education， China Medical University， Shenyang 110122， China)

Abstract: Abstract: Recently， more and more researches reported that estrogen receptors play roles in the progression and development of thyroid cancer. Compared with normal thyroid tissue and nodular hyperplasia tissue， the expression of various ERs has different changes; the expression of various ERs in PTC are related to important tumor makers such as Ki67， mutant P53 and VEGF; ERα directly interacts with IQGAP1 during the progression of thyroid cancer; ERα increases the expression of Hsp27 in thyroid cancer， and so on. These results determine the effects of ERs on pathological process of thyroid cancer such as proliferation， invasion and metastasis. However， it is not clear that the impacts of various ERs towards thyroid carcinoma. The review will discuss the related researches of ERs and thyroid carcinoma.