《生命科学》 2017, 29(5): 479-484

PPARα在肝脏相关疾病中作用的研究进展

朱书彤1，赵　越2*

(1 中国医科大学七年制，沈阳110122；2 中国医科大学基础医学院，卫生部细胞生物学重点实验室，教育部医学细胞生物学重点实验室，染色质生物学研究室，沈阳 110122)

摘　要：摘　要：过氧化物酶体增殖物激活受体α (perixisome proliferation-activated receptor alpha， PPARα) 是核受体超家族成员，是参与肝脏β 氧化的主要调控蛋白，通过诱导下游靶基因转录，从而发挥其重要的生物学功能。近年来，肝脏相关疾病的研究备受关注，肝癌( 主要以肝细胞性肝癌为主) 也呈年轻化趋势。PPARα 的活化能够降低高脂喂养小鼠肝脏中甘油三酯的含量或脂肪的生成量。此外，PPARα 通过调控细胞增殖与凋亡进程等多种机制参与肝癌进程。现综述PPARα 在非酒精性脂肪肝、酒精性脂肪肝和肝细胞性肝癌进程中的作用。

Research process of PPARα in liver diseases

ZHU Shu-Tong1， ZHAO Yue2*

(1 Seven-year Postgraduate， China Medical University， Shenyang 110122， China; 2 Laboratory of Chromatin Biology，Department of Cell Biology， Key Laboratory of Public Health of China， Department of Medical Cell Biology of Ministry of Education， China Medical University， Shenyang 110122， China )

Abstract: Abstract: Perixisome proliferation-activated receptor alpha (PPARα) belongs to nuclear receptor superfamily， and acts as the major regulator of liver β-oxidation. PPARα exerts its important biological functions through inducing the transcription of its downstream target genes. In recent years， researches concerning liver diseases gain lots of attention， and patients with liver cancer (mainly refers to hepatocellular carcinoma) become younger in average age. The activation of PPARα reduces the level of liver triglyceride or liver fat in mice feeding with high-fat diet. Moreover， PPARα participates in the progression of hepatocellular carcinoma via modulating cell proliferation and apoptosis. Here， we review the roles of PPARα in the progression of non-alcoholic fatty liver， alcoholic fatty liver and hepatocellular carcinoma.