《生命科学》 2017, 29(5): 473-478

糖尿病及其并发症与DNA损伤、修复的研究进展

施佳晨，张　旭，孙建宁，梁耀月，李佳佳，董世芬*

(北京中医药大学中药学院中药药理系，北京 100102)

摘　要：摘　要：糖尿病(diabetes mellitus， DM) 是由多种环境因素、遗传因素联合作用导致慢性高血糖状态的全身代谢性疾病，易并发形成心血管、视网膜、肾脏、神经等病变，发病机制复杂，严重危害人类健康。目前DNA 损伤、修复在DM 及其并发症的发生发展和防治过程中的作用受到重视，现就DNA 损伤与修复过程中多聚(ADP 核糖) 聚合酶[Poly (ADP-ribose) polymerase， PARP] 功能、8- 羟基鸟嘌呤(8-hydroxy-2’-deoxyguanosine，8-OhdG) 修复通路、X 射线修复交叉互补基因(X-ray repair cross-complementing gene， XRCC) 多态性变异、Nei 核酸内切酶Ⅷ样蛋白1 (nei endonuclease Ⅷ -like 1， NEIL1) 基因多态性变异和Chk 基因细胞周期检测点激酶(checkpoint kinase， Chk) 多态性变异与DM 及并发症的关系展开综述。

DNA damage and repair in diabetes mellitus and its complications

SHI Jia-Chen， ZHANG Xu， SUN Jian-Ning， LIANG Yao-Yue， LI Jia-Jia， DONG Shi-Fen*

(Department of Pharmacology， School of Chinese Materia Medica， Beijing University of Chinese Medicine， Beijing 100102， China)

Abstract: Abstract: Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion， insulin action， or both， which could have long lasting adverse effects on nation’s health and economy. Long-term complications of diabetes include retinopathy， nephropathy， autonomic neuropathy， cardiovascular symptoms， and etc. The interaction between multiple genetic and environmental factors is involved in the pathogenesis progress of DM. Among multiple pathophysiologic mechanisms leading to DM， the damage and repair of DNA have received much attention. This paper summarized the poly ADP ribose polymerase function，8-hydroxy guanine repair pathway， and the polymorphism mutation of X-ray repair cross-complementing gene， Nei endonuclease Ⅷ-like 1 gene and Checkpoint kinase gene in the process of DNA damage and repair during the occurrence of diabetes and its complications.