《生命科学》 2017, 29(5): 450-461

MHC分子抗原递呈机制的研究进展

高　花，韩　勇，翟晓鑫，高凤山*

(大连大学生命科学与技术学院基因和蛋白质工程实验室，大连 116622)

摘　要：摘　要：MHC 分子限制性抗原递呈机制在细胞免疫应答中占有绝对重要地位，对MHC 抗原递呈机制的研究一直是免疫学研究的热点。尽管抗原分子经过MHC 分子递呈和加工机制已经被研究了近40 年，且抗原递呈机制的基本途径已经在10 年前基本阐明，但近几年仍发现MHC 一些新的递呈机制和特点。MHC 分子抗原递呈过程十分繁琐，涉及许多蛋白质、分子伴侣等之间的相互作用。现综述了MHC 分子所递呈限制性抗原的产生、运输以及抗原交叉递呈等方面的最新研究进展。

The research progress of antigen presentation by MHC molecules

GAO Hua， HAN Yong， ZHAI Xiao-Xin， GAO Feng-Shan*

(Gene and Protein Engineering Laboratory in College of Life Science and Technology of Dalian University， Dalian 116622， China)

Abstract: Abstract: The mechanism for major histocompatibility complex (MHC) to present restrictive antigens， absolutely occupied an important position in cell immune responses. It is still a hotspot to study the antigen-presented mechanism of MHC in immunology. Although the mechanism had been studied for nearly 40 years， and the basic presentation ways had been elucidated for 10 years， some new processing ways and specificity for MHC have been reported in recent years. Totally， the antigen-presented process for MHC molecules is very complicated because it is related to interaction with many proteins， chaperones， et al. In this article， the latest research development will be reviewed， including the production of the restrictive antigen presentation by MHC in cells， transportation intracellularly and extracellularly， and the cross-presentation for MHC molecules.