《生命科学》 2005, 17(1): 49-54

线粒体渗透性转变孔结构和功能的研究进展

郭虹霞，余长缨，陈　静，蒋华良，沈　旭*

中国科学院上海生命科学研究院上海药物研究所，中国科学院研究生院，上海 201203

摘　要：摘　要：非正常生理浓度的Ca2+和氧化应激等刺激线粒体渗透性转变孔(mitochondria permeability transition pore， MPTP)开放，使线粒体形态功能发生改变，被释放的细胞色素c和凋亡诱导因子(apoptosis-inducing factor， AIF)等参与到caspase信号通路中，诱导细胞发生凋亡。本文在MPTP的主要组成成分、两种不同的结构功能模型、抑制剂对MPTP的抑制机制和缺血/再灌注及缺血预适应对MPTP开放的影响等方面的研究进展作一综述。
关键词：线粒体渗透性转变孔；腺苷酸转运蛋白；亲环素D；电压依赖性阴离子通道；环孢素A

Progress in the studies of the structure and function of mitochondria permeability transition pore

GUO Hong-Xia， YU Chang-Ying， CHEN Jing， JIANG Hua-Liang， SHEN Xu*

Shanghai Institute of Materia Medica， Shanghai Institutes for Biological Sciences， Chinese Academy of Sciences， Graduate School of CAS， Shanghai 201203， China

Abstract: Abstract: .Abnormally high concentration of Ca2+ and oxide stress can stimulate the opening of the mitochondria permeability transition pore (MPTP) and cause the change of mitochondria shape and function. The factors released by mitochondria， such as cytochrome c and AIF (apoptosis-inducing factor) involve in the signaling pathway of caspases and induce cell apoptosis. This article describes the recent progress in the studies of the main components and two different models of the MPTP， the mechanism of the inhibition of CSA and SfA to MPTP and the influence of ischemia /reperfusion and ischaemic preconditioning to the opening of MPTP.
Key words: MPTP (mitochondria permeability transition pore); ANT (adenine nucleotide translocator); CypD (cyclophilin D); VDAC (voltage-dependent anion channel); CSA (Cyclosporin A)