《生命科学》 2017, 29(5): 415-420

分枝杆菌Lsr2蛋白的结构、功能及其与结核病防控

肖佳妮，陈颖盈，王　颖*

(上海交通大学医学院上海市免疫学研究所，上海 200025)

摘　要：摘　要：结核病是由结核分枝杆菌(M. tuberculosis， M. tb) 感染引起的传染病，目前对于结核潜伏感染状态的维持和防止再激活成为结核病防控的关注热点和研究方向。Lsr2 属于M. tb 中的拟核结合蛋白，具有H-NS样结构域，在M. tb 对氧浓度变化的适应中具有重要作用。作为一个全局性的转录调控因子，Lsr2 调控结核分枝杆菌的蛋白表达，参与潜伏感染状态的维持，并可能成为针对活动性结核病和结核潜伏感染的候选靶抗原。现围绕Lsr2 的生物学特性和在结核病防控中的意义进行论述。

Biological property of Mycobacterial Lsr2 and its significance in tuberculosis control

XIAO Jia-Ni， CHEN Ying-Ying， WANG Ying*

(Shanghai Institute of Immunology， Shanghai Jiao Tong University School of Medicine， Shanghai 200025， China)

Abstract: Abstract: Tuberculosis (TB)， which is caused by Mycobacterium tuberculosis (M. tb) infection， remains one of the most severe infectious diseases worldwide. Prevention against resuscitation of latent M. tb infection as well as maintenance of latent infection are important for TB control. Lsr2 is a newly identified molecule in M. tb， containing H-NS-like functional domain. It belongs to nucleoid-associated protein (NAP) family. Lsr2 plays key roles in the adaptation to the alteration of oxygen levels. Being a global transcriptional regulator， Lsr2 regulates panels of gene expression， most of which are related to bacterial latency and the survival of M. tb during latent infection in the host. Herein we summarized the latest research progresses in the biological properties of Lsr2. Its potential application in vaccine designing against active TB and latent TB infection were further expected.