《生命科学》 2017, 29(4): 386-392
摘 要：摘 要：近年来，包括姜黄素、姜黄素衍生物及复合物在内的姜黄家族的抗肿瘤能力已被越来越多的学者所关注，成为现代抗肿瘤研究的热点。姜黄素的去甲氧基化、氨基化、烯酮类、萜烯类等官能团修饰能通过提高姜黄素的水溶性和稳定性，提高其生物利用度，改善药代动力学，增强其抗癌能力。氧钒(vanadyl，IV) 复合物、烷氧基联苯/ 姜黄素偶联物、姜黄素与磺丁基醚-β 环糊精包被而成的复合物也均对肿瘤细胞有不同的杀伤抑制作用。现对几年来国内外姜黄素衍生物及复合物抗肿瘤的研究进行总结，旨在为进一步认识姜黄素的抗肿瘤机制，并对姜黄素进行改造提供思路。
Abstract: Abstract: The anti-tumor ability of turmeric family including curcumin， curcumin derivatives and complexes has been receiving attention and become a modern anti-cancer research hotspot in recent years. Curcumin can be modified by adding or removing some functional groups or atoms， such as methoxylation， amination， ketenes， terpenes and so on. These derivatives have higher bioavailability， solubility， stability， and anti-cancer ability. Curcumin vanadyl (IV) composites， the alkoxy biphenyl/curcumin， and the composites coated by curcumin and sulfobutyl ether β-cyclodextrim can kill or prevent the growth of tumor cell by different mechanisms. This paper summarized the recent studies on the anti-cancer effects of curcumin derivatives and curcumin complexes， which aims to get further understanding for the anti-tumor mechanism of curcumin， and provide ideas for modification.
