《生命科学》 2017, 29(4): 380-385

Cofilin在疾病中的研究进展

汪　阳，赵淑玲，丁　冬，汤立军*

(中南大学生命科学学院医学遗传学国家重点实验室，长沙 410078)

摘　要：摘　要：Cofilin 是一种肌动蛋白结合蛋白，属于肌动蛋白解聚因子家族成员，普遍存在于真核细胞。它与肌动蛋白微丝(F-actin) 结合，调节F-actin 的解聚和重构。Cofilin 具有多种生物学功能，如参与肌动蛋白骨架重组、核转运、胞质分裂以及心血管生成等。在应激条件下，cofilin 可通过相应作用通路进行调节，改变细胞的功能。Cofilin 在多种疾病如肿瘤、神经系统性疾病、血管性疾病、感染性疾病等的发生与发展中都起到了非常重要的作用。

Research progress of cofilin in diseases

WANG Yang， ZHAO Shu-Ling， DING Dong， TANG Li-Jun*

(The State Key Laboratory of Medical Genetics ， School of Life Sciences，
    Central South University， Changsha 410078， China)

Abstract: Abstract: Cofilin is a kind of actin-binding protein. It belongs to the family member of actin depolymerization factors which ubiquitously exists in eukaryotic cells. Cofilin byinds to actin filament (F-actin) and mediates the depolymerization and reorganization of F-actin. It has a variety of biological functions， such as involvement in the restructuring of actin cytoskeleton， nuclear transfer， cytokinesis as well as the formation of cardiovascular system and so on. Cofilin can mediate the function of the cells through the corresponding pathway with environmental stress. Cofilin plays a pivotal role in the occurrence and development of many kinds of diseases such as cancer， neurological diseases， vascular diseases， infectious diseases.