《生命科学》 2017, 29(4): 331-335

葡萄糖调节蛋白78的研究进展

麻庆乐，卢德赵*

(浙江中医药大学生命科学学院，杭州 310000)

摘　要：摘　要：葡萄糖调节蛋白78(glucose regulated protein 78 kD， GRP78) 是位于内质网上的重要分子伴侣，在蛋白质折叠和转运过程及内质网应激反应中发挥重要作用。近年来发现，GRP78 高表达与多种疾病发生发展密切相关，其生物学功能受到广泛关注。现综述国内外文献，对GRP78 的生物学功能及与肿瘤、心血管疾病、糖尿病之间的关系进行分析与研究，为临床疾病治疗靶点提供理论依据。

Research progress on GRP78

MA Qing-Le， LU De-Zhao*

(College of Life Science， Zhejiang Chinese Medical University， Hangzhou 310000， China)

Abstract: Abstract: Glucose-regulated protein 78 (GRP78) is an important chaperone located in the endoplasmic reticulum， playing an important role in protein folding and transport as well as endoplasmic reticulum stress. In recent years， it has been found GRP78 overexpression is closely related to the development of several diseases. The biological function of GRP78 has attracted widespread attention. The relationship between the biological function of GRP78 and cancer， cardiovascular disease， diabetes is reviewed， providing a theoretical basis for the targets of clinical treatment.