《生命科学》 2005, 17(1): 82-87

计算方法在蛋白质相互作用研究中的应用

曹建平¹，马义才¹，李亦学²，石铁流^2*

1电子科技大学生命科学与技术学院，成都 610054;2 中国科学院上海生命科学研究院生物信息中心，上海 200031

摘　要：摘　要：计算方法在蛋白质相互作用研究的各个阶段扮演了一个重要的角色。对此，作者将从以下几个方面对计算方法在蛋白质相互作用及相互作用网络研究中的应用做一个概述:蛋白质相互作用数据库及其发展；数据挖掘方法在蛋白质相互作用数据收集和整合中的应用；高通量方法实验结果的验证；根据蛋白质相互作用网络预测和推断未知蛋白质的功能；蛋白质相互作用的预测。
关键词：蛋白质相互作用数据库；蛋白质功能预测；蛋白质相互作用网络；蛋白质间相互作用

The application of the computational methods in protein-protein interaction study

CAO Jian-Ping¹， MA Yi-Cai¹， LI Yi-Xue²， SHI Tie-Liu^2*

1 College of Life Science and Technology， UESTC， Chengdu 610054， China; 2 Bioinformation Center， Shanghai Institutes for Biological Sciences， Chinese Academy of Sciences， Shanghai 200031， China

Abstract: Abstract: Computational methods play an important role at all stages of the process of determining protein-protein interactions. Here， computational methods dealing with protein-protein interactions and interaction network are discussed from five aspects: interaction databases with their construction and development; automated data mining techniques developed to extract information about interactions from the published literature; computational methods used for the assessment of the results of high-throughput approaches;  exploitation of the information provided by protein interaction networks for predicting functional features of the proteins; computational methods adopted for predicting protein-protein interactions.
Key words:  protein interaction database; protein function prediction; protein interaction networks; protein-protein interaction