《生命科学》 2017, 29(2): 164-169

脂肪酸结合蛋白研究进展

田　鎏，张昌军*，刁红录

(湖北医药学院附属人民医院生殖医学中心，十堰 442000)

摘　要：摘　要：脂肪酸结合蛋白(fatty acid binding proteins， FABPs) 家族目前已知类型有12 种，主要表达在哺乳动物的各种组织中，具有组织表达的特异性。脂肪酸结合蛋白的主要功能是进行脂肪酸的转运，特别是多不饱和脂肪酸的转运。脂肪酸结合蛋白还具有许多其他的生物学功能，如影响血管的生成和细胞的增殖分化等。而在哺乳动物胎盘形成的过程中，FABPs 也起着重要作用。FABPs 还与许多代谢综合征等疾病的发生发展密切相关。现主要对脂肪酸结合蛋白的功能、与生殖过程和疾病的关系作一综述。

Advances in fatty acid binding proteins research

TIAN Liu， ZHANG Chang-Jun*， DIAO Hong-Lu

(Reproductive Medicine Center， Renmin Hospital， Hubei University of Medicine， Shiyan 442000， China)

Abstract: Abstract: Fatty acid binding proteins (FABPs) family currently has 12 kinds of known types， which have different expression in various tissues of mammals. The main function of FABPs is to transport fatty acids， particularly polyunsaturated fatty acids. Moreover， FABPs also have many other biological functions， such as influencing the angiogenesis， cell differentiation and proliferation and playing an important role in the process of placentation in mammals. Further more FABPs is closely related to the pathogenesis of many diseases such as metabolic syndrome. In this paper， we aim to review the functions of FABPs， and their relationship with the progress of reproduction and diseases.