《生命科学》 2017, 29(2): 160-163

聚谷氨酸衍生物及其在生物医药领域中的应用

耿　旭*，林　波，谢振兴，叶文凌

(河南大学医学院，开封 475004)

摘　要：摘　要：聚谷氨酸衍生物是在γ- 聚谷氨酸的基础上发展而来的，具有独特的结构和性能，在医药领域中有潜在的应用价值。聚谷氨酸衍生物按照其设计和制备特点，可分成3 种类型：γ- 聚谷氨酸修饰衍生物、含谷氨酸结构单元的衍生物和γ- 聚谷氨酸交联衍生物。现分别介绍不同类型衍生物的合成思路、性质特征和具体应用。这将有助于γ- 聚谷氨酸衍生物在医药领域的研究和应用，同时也能为这一领域其他高分子材料的开发提供借鉴。

Poly (glutamic acid) derivatives and their application in biomedical fields

GENG Xu*， LIN Bo， XIE Zhen-Xing， YE Wen-Ling

(Medical College of Henan University， Kaifeng 475004， China)

Abstract: Abstract: Poly (glutamic acid) derivatives which are developed on base of poly (γ-glutamic acid) have unique structure and performance and have potential application in the field of medicine. According to the characteristics of its design and preparation， poly (glutamic acid) derivatives can be divided into three types: derivatives of poly(γ-glutamic acid) modified， derivatives containing structural unit of glutamate and derivatives of poly (γ-glutamic
    acid) cross-linked. This review introduced synthesis methods， characteristics and application of different types of derivatives respectively. This will contribute to the research and application of poly (glutamic acid) derivatives in biological and medical fields， and it also can provide reference for other polymer materials development in the field.