《生命科学》 2017, 29(2): 122-130

DBC1的蛋白质结构与生物学功能的研究进展

窦剑明，艾乐飞拉·艾合买提，谢文娟，乔守怡*，吴燕华*

(复旦大学生命科学学院，上海 200438)

摘　要：摘　要：乳腺癌缺失因子1 (deleted in breast cancer 1， DBC1) 编码一个含有多个功能结构域的核蛋白，能够与染色质修饰蛋白、核受体等多种蛋白互作，参与调节基因转录与信号转导，在代谢、衰老、炎症和肿瘤等方面发挥重要作用。现从蛋白质结构与功能、互作蛋白与信号途径、肿瘤表达谱等3 个方面对DBC1 的研究进展进行简要阐述。

Research progress on the protein structure and biological function of DBC1

DOU Jian-Ming， Elphire Ehmed， XIE Wen-Juan， QIAO Shou-Yi*， WU Yan-Hua*

(School of Life Sciences， Fudan University， Shanghai 200438， China)

Abstract: Abstract: Deleted in breast cancer 1 (DBC1) encodes a nuclear protein with multiple functional domains. DBC1 protein is able to regulate gene transcription and intracellular signal transduction through interacting with chromatin epigenetic modifiers， nuclear receptors and many others. It is demonstrated that DBC1 is involved in metabolism， aging， inflammation and cancer. In this review， we will briefly discuss the new development and findings in DBC1， its protein structure， interacting proteins， signaling pathway and its expression pattern in cancer.