《生命科学》 2017, 29(1): 62-69
摘 要：摘 要：Edar 信号通路最早发现于人少汗型外胚层发育不良综合征(hypohidrotic ectodermal dysplasia， HED)疾病患者，它是调控胚胎发育早期皮肤附属物—— 头发、指甲、牙齿、外分泌腺等的形态发生、发育过程的重要信号通路。与人类相同，小鼠皮肤内毛囊于胚胎期发生并发育成熟，出生后进入动态变化的毛囊周期性生长。小鼠模型的相关研究表，Edar 信号通路在早期初级毛囊的发生、成体毛囊周期性生长和被毛纤维直径等方面都发挥重要的调控作用。现综述Edar 通路中重要信号分子的结构特点、转导途径及其在皮肤和毛囊早期形态发生中的作用；阐述Edar 信号通路对毛囊生长周期的调控，对维持皮肤微环境稳态、促进皮肤损伤修复和表皮再生的作用，以及在临床治疗HED 相关疾病方面的潜在应用前景。
Abstract: Abstract: Edar signaling pathway， which was initially characterized from hypohidrotic ectodermal dysplasia (HED) syndrome， plays an important role in morphogenesis and development of ectodermal appendages including hair，nails， teeth， exocrine glands， etc. In mice， hair follicles initiate and develop in embryonic stage and go through cyclic growth after birth which are regulated by many signaling pathways. Of those， Edar is one of the key stimulator for primary hair follicle formation and highly associated with hair fiber thickness in adulthood. This review illucidates the function of Eda/Edar/Edaradd signaling pathway on hair follicle development and cycling， wound healing and skin tissue homeostasis， and speculates the potential clinical application for HED-associated disorder targeted on Eda/Edar genetic variants.
