《生命科学》 2016, 28(11): 1314-1320

谷氨酸脱氢酶的基本特性及其与疾病的相关研究进展

徐晓光1，朱　静1，2，师俊玲1*，邵东燕1，黄庆生1

(1 西北工业大学生命学院空间生物实验模拟技术重点实验室，西安 710072；2 信阳农林学院食品学院，信阳 464000)

摘　要：摘　要：谷氨酸脱氢酶(GDH) 存在于所有生物体中，在三羧酸循环、氨代谢调控、能量产生和信号转导中起着重要作用。关于GDH 的研究报道已有很多，涉及到植物氮代谢、微生物生理、动物神经调节以及其本身的生产应用，但有关其与人类疾病间关系的文献综述尚未见报道。在对GDH 基本特性进行归纳和总结的基础上，对其与高胰岛素- 高血氨综合征、帕金森病，以及不同癌症间关系等方面的最新研究进展进行了综述，以期为相关研究提供参考。

Characteristics of glutamate dehydrogenase and its effect on diseases

XU Xiao-Guang1， ZHU Jing1，2， SHI Jun-Ling1*， SHAO Dong-Yan1， HUANG Qing-Sheng1

(1 Key Laboratory for Space Bioscience and Space Biotechnology， School of Life Sciences， Northwestern Polytechnical University， Xi’an 710072， China; 2 Department of Food Science， Xinyang College of Agriculture and Forestry， Xinyang 464000， China)

Abstract: Abstract: Glutamate dehydrogenase (GDH) exists in all living organisms and plays an important role in the Krebs cycle， ammonia metabolism regulation， energy production and cell signaling. Many researches have been carried out on GDH in recent years， including plant nitrogen metabolism， microbial physiology， animal neural regulation and its application in industrial production. However， there is still lack of comprehensive review on the relationship between this enzyme and human diseases. Therefore， this article reviewed the new development in the characteristics of GDH， and its relationship with some diseases， especially with hyperinsulinism/hyperammonemia syndrome， Parkinson's disease and cancers to provide useful information for relative researches in the future.