《生命科学》 2016, 28(9): 1067-1074

布鲁氏菌免疫应答研究进展

冯　宇1，2，丁家波1*

(1 中国兽医药品监察所检测技术室，北京 100081；2 山东农业大学动物科技学院，泰安 271018)

摘　要：摘　要：布鲁氏菌病是一种由布鲁氏菌(Brucella) 引起的人兽共患病，严重威胁家畜的健康养殖和人类健康。布病的发生和发展受到宿主、病原以及病原在宿主巨噬细胞内定殖等多种因素的影响。布鲁氏菌能在单核细胞尤其是巨噬细胞中生存，并引起机体产生免疫反应，但也是布病难以治愈的原因之一。探究和分析布鲁氏菌引起的免疫应答反应对于布病防控和新型疫苗开发具有重要的意义。现有研究发现，巨噬细胞的主动防御机制、树突状细胞以及由CD4+ 和CD8+ 亚群介导产生的IFN-γ、IL-12 和TNF-α 对于抵抗布鲁氏菌的感染十分重要，有关布鲁氏菌特异性免疫应答反应的研究大多集中于小鼠模型。现结合实验室自身研究内容，就国内外布鲁氏菌免疫或感染不同宿主后引起的免疫应答反应进展作一综述。

Research advance on immune response against Brucella

FENG Yu1，2， DING Jia-Bo1*

(1 Department of Inspection Technology Research， China Institute of Veterinary Drug Control， Beijing 100081， China; 2 College of Animal Science And Veterinary Medicine， Shandong Agriculture University， Tai’an 271018， China)

Abstract: Abstract: Brucellosis is a zoonotic and contagious infectious disease caused by infection with Brucella species， threatening livestock and human health seriously. The pathogenesis of Brucella infection is mainly influenced by host factors， Brucella species/strain， the ability of invading Brucella to survive and replicate within mononuclear phagocytic cells， preferentially macrophages. These are the reasons that brucellosis was hard to heal. Understanding the protective immune responses triggered by Brucella is critical for the development of new vaccines， and prevention and control of brucellosis. Active participation of macrophages， dendritic cells， IFN-γ， IL-12 and TNF-α produced by CD4+ T-cells and cytotoxic CD8+ T-cells are vital to fight the infection. Most of our understanding about protective immune response against Brucella infection comes from studies using mouse model. Based on the author’s own research in this field， this paper makes a summary on research progress of the immune response against Brucella infection/vaccination in various hosts.