《生命科学》 2016, 28(9): 1044-1053

miR-185生物学功能的研究进展

宁椿游1，2，游　路1，2，李贵林1，2，李明洲1，2，刘海峰1，2*

(1 四川农业大学动物科技学院动物遗传育种研究所，成都 611130；2 四川农业大学畜禽遗传资源发掘与创新利用四川省重点实验室，成都 611130)

摘　要：摘　要：miRNAs 是近几年分子生物学领域的研究热点，主要介导基因的转录后调控，进而对机体的生命活动产生广泛影响。miR-185 首次在人神经母细胞瘤中被鉴别出来，并被定位于22q11.21。越来越多的研究发现，miR-185 可通过靶向不同基因参与细胞增殖、分化和凋亡等生命过程。在细胞癌变、恶性肿瘤的发生以及脂质代谢中扮演着重要的角色，并被作为肿瘤诊断、治疗和预后相关的标志物之一。现主要对miR-185 在恶性肿瘤、脂质代谢及糖尿病等方面的调节机制进行详细阐述，旨在为miR-185 的生物学功能及作用机制的深入研究提供参考。

The biological function of miR-185

NING Chun-You1，2， YOU Lu1，2， LI Gui-Lin1，2， LI Ming-Zhou1，2， LIU Hai-Feng1，2*

(1 Institute of Animal Genetics and Breeding， College of Animal Science and Technology， Sichuan Agricultural University， Chengdu 611130， China; 2 Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan
    Province， Sichuan Agricultural University， Chengdu 611130， China)

Abstract: Abstract: miRNAs， research focus of molecular biology in recent years， regulated genes at post-transcriptional levels to exert an influence on cellular activities of organism. miR-185 was identified firstly in human neuroblastoma cells， located in 22q11.21. Increasing number of studies have profiled that miR-185 was involved in cell proliferation， differentiation and apoptosis by means of targeting different genes. It exerted a vital role in carcinogenesis， generation of malignancy and lipid metabolism， and was also considered as one of potential tumor markers of tumor therapy and prognosis. In this review， the regulation mechanism of miR-185 in malignant tumor， lipid metabolism and diabetes was elaborated， aiming to provide theoretical foundation of researching biological function and mechanism of miR-185.