《生命科学》 2016, 28(9): 1025-1032

溶瘤病毒与肿瘤治疗

潘海娇，陈　琴，黄承浩*，夏宁邵

(厦门大学公共卫生学院，分子疫苗学和分子诊断学国家重点实验室，国家传染病诊断试剂与疫苗工程技术研究中心，厦门 361102)

摘　要：摘　要：溶瘤病毒是目前恶性肿瘤治疗领域中较有前景的新型基因治疗药物，其通过选择性杀伤肿瘤细胞和诱导机体产生特异的抗肿瘤免疫两种途径来实现肿瘤靶向治疗的目的，从而达到较好的抗肿瘤效果。现对溶瘤病毒的溶瘤机制、临床研究、联合治疗和当前挑战及未来展望等方面进行综述。

Oncolytic virus and cancer therapy

PAN Hai-Jiao， CHEN Qin， HUANG Cheng-Hao*， XIA Ning-Shao

(State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics， National Insitute of Diagnostics and Vaccine Development in Infectious Diseases， School of Public Health， Xiamen University， Xiamen 361102， China)

Abstract: Abstract: Oncolytic virus are therapeutically promising anticancer viruses that selectively kill cancer cells and induce host anti-tumor immune responses. This review summarizes recent advances and progress in oncolytic virotherapy， including oncolytic mechanism， clinical study， combined therapy， challenges and future prospects.