《生命科学》 2016, 28(8): 888-894

利用多能干细胞技术研究和治疗衰老相关疾病

刘尊鹏1，赵　洋2，曲　静1* ，张维绮2* ，刘光慧2*

(1 中国科学院动物研究所，干细胞与生殖发育国家重点实验室，北京 100101； 2 中国科学院生物物理研究所，生物大分子国家重点实验室，北京 100101)

摘　要：摘　要：人类衰老是复杂的生物学过程，主要表现为组织、器官的功能性衰退以及衰老相关疾病风险的增加。多能性干细胞(PSC) 是指具有多向分化潜能的细胞，主要包括胚胎干细胞(ESC) 和诱导多能干细胞(iPSC)。多能干细胞技术的飞速发展和广泛应用为衰老及老年性疾病的科学研究和药物筛选提供了重要的平台。同时，日新月异的基因靶向编辑技术为衰老及相关疾病的干预及治疗提供了可行性。基于人类干细胞和基因编辑技术的衰老基础研究及应用具有重要的科学意义和社会价值。

Using pluripotent stem cell technique to study and treat aging-related diseases

LIU Zun-Peng1， ZHAO Yang2， QU Jing1*， ZHANG Wei-Qi2*， LIU Guang-Hui2*

(1 State Key Laboratory of Stem Cell and Reproductive Biology， Institute of Zoology， Chinese Academy of Sciences， Beijing 100101， China; 2 National Laboratory of Biomacromolecules， Institute of Biophysics， Chinese Academy of Sciences， Beijing 100101， China)

Abstract: Abstract: Aging is a complex biological process， embodied by functional decline of organs and tissues， and the increasing risk of aging-related diseases. Pluripotent stem cells (PSC) including embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC)， have the capacity of self-renewal and to differentiate into multiple types of cells. The blooming PSC technologies open up a new prospect for studying human aging and aging-related diseases， as well as developing relevant treatment. Additionally， gene editing techniques provide the feasibility of intervention of aging and age-associated diseases. Development in individualized treatment of human aging based on stem cell and gene editing techniques has broad scientific significance and social value.