《生命科学》 2016, 28(8): 849-855

中胚层细胞谱系研究

杨雯隽，胡　苹*

(中国科学院上海生命科学研究院生物化学与细胞生物学研究所，细胞生物学国家重点实验室，上海 200031)

摘　要：摘　要：深入认识中胚层细胞谱系产生和发育分化过程有助于体外获得大量可用于移植的、有功能的中胚层来源成体干细胞，为基础科学和再生医学治疗提供理论指导。中国科学院战略性科技先导专项“干细胞与再生医学研究”项目内的中胚层研究，以肌肉和血液两个中胚层来源细胞谱系决定为切入点，探讨中胚层细胞谱系在发育分化过程中的重要功能和调控机制，建立成体干细胞体外扩增培养体系，为中胚层来源干细胞的自我更新、迁移增殖和定向分化研究提供重要的理论基础，并为中胚层系统疾病提供治疗靶点和细胞来源。现将对先导项目启动五年来开展的研究内容及其取得的研究成果进行介绍。

Study on mesodermal cell lineages

YANG Wen-Jun， Hu Ping*

(State Key Laboratory of Cell Biology， Institute of Biochemistry and Cell Biology，
    Shanghai Institutes for Biological Sciences， Chinese Academy of Sciences， Shanghai 200031， China)

Abstract: Abstract: The study on the derivation of cell type patterns in mesoderm and dissecting their development and differentiation processes， are critical in generating functional and transplantable mesoderm derived stem cells， rendering the applications of regenerative medicine. The mesoderm study belongs to a part of a project “the research on the stem cells and regenerative medicine” in Strategic Priority Research Program of the Chinese Academy of Sciences. This project focused on two mesoderm derived cell types， muscle and blood. We investigated the features and regulatory mechanisms in the development and differentiation of mesoderm cell types， and found novel factors that can maintain the stemness of progenitor cells. Based on these findings， we constructed the large-scale cultivation and proliferation system， in vitro. This study will provide valuable information for profound understanding of the self-renew， proliferation and differentiation of mesoderm derived stem cells. This article will review the research progress of the five-year project.